It is a crystalline compound that is white in colour and is slightly soluble in water. Calculate the mass, volume or concentration required for a solution. Jump to main content Jump to site nav. Calculate the dilution required to prepare a stock solution. 3.2.7Kovats Retention Index. Cinnamic acid is a polyphenol and an antioxidant. COVID-19 is an emerging, rapidly evolving situation. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Mol Med Rep. 2016, 13(5):4159-66. The solid solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide were measured using a semi-flow apparatus. BAPTA-AM is a selective, membrane-permeable calcium chelator. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants.It exists as both a cis and a trans isomer, although the latter is more common. Cinnamic acid has been reported to exhibit antioxidant and antibacterial activities [63–69]. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. It exists as both a cis and a trans isomer, although the latter is more common. Ganciclovir (RS-21592, BW-759) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. The solubilities of three cinnamic acid esters, namely, methyl ferulate, methyl p -coumarate, and methyl sinapate, in eight imidazolium-based ionic liquids composed of the PF 6− and BF 4− anions have been measured at (30, 39, and 48) °C. C Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid has the formula C6H5CHCHCOOH and is an odorless white crystalline acid, which is slightly soluble in water. [2] Zhu B, et al. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. The color of the native bilberry anthocyanin solution dissolved in ethyl acetate and dioxane was transparent. With the CAS number 140-10-3, it is also called trans-Cinnamic Acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid, (E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. 12 x 10. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. ChEBI Ontology Outgoing trans-cinnamic acid (CHEBI:35697) has role plant metabolite (CHEBI:76924) trans-cinnamic acid (CHEBI:35697) is a cinnamic acid (CHEBI:27386) trans-cinnamic acid (CHEBI:35697) is conjugate acid of trans-cinnamate (CHEBI:15669) Cinnamic acid exists in all living organisms, ranging from bacteria to humans. 2013, 32:31. Catalog No.S3677 Linear Formula C 6 H 5 CH=CHCOOH . 66 x 100 = 64.8%. Maximised Survey-derived Daily Intakes (MSDI-EU): 28.00 (μg/capita/day) Maximised Survey-derived Daily Intakes (MSDI-USA): 44.00 (μg/capita/day) Structure Class: I: Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances … The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). PubChem Substance ID 24848120 DMSO master liquid, next addμL PEG300, mix and clarify, next addμL 16 / 106. drug pre-dissolved in μL DMSO (Master liquid concentration Cinnamic acid is an organic compound with the formula C 6 H 5 CH=CHCOOH. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. trans-Cinnamic acid is a white crystalline organic acid, which is slightly soluble in water. In this short piece of article, we shall be discussing more about the cinnamic acid We do not sell to patients. (1 u is equal to 1/12 the mass of one atom of carbon-12) Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. Method for preparing in vivo formulation:Take μL It has a role as a plant metabolite. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. Synonyms: trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. It is obtained from oil of cinnamon, or from balsams such as storax. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. TLC and 1H NMR analysis confirm the purity of final product, without any cinnamic acid contamination, and thus it is not necessary to make any recrystallization. Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. Recommendation for cinnamic acid usage levels up to: 2.0000 % in the fragrance concentrate. The percentage yield of the Cinnamic acid is about 64.8% of melting point 132 °C. Free Overnight Delivery on orders over $ 500 CONCLUSION . Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The username will be used as the login user name and retrieve the password, Copyright 2017 © ChemicalBook. C10H16N2O2 c10h16n2o2. ). Structure, properties, spectra, suppliers and links for: Cinnamic acid, phenyl ester, 2757-04-2. Tel: +1-832-582-8158    Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE)    0207 4594182 (UK)Fax: 030 4036821 99 (DE)    0207 4594183 (UK)Email:[email protected]. Products are for research use only. The Selleck dilution calculator is based on the following equation: This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output ). Cinnamic acid is an organic compound with the formula C6H5CHCHCO2H. mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Method for preparing DMSO master liquid: : mg 2.Be sure to add the solvent(s) in order. The original synthesis of … Cinnamic acid is also a kind of self-inhibitor produced by fungal spore to prevent germination. Chemical Properties Cinnamic acid is almost odorless with a burning taste, and … - Find MSDS or SDS, a COA, data sheets and more information. MDL number MFCD00004369. This is normal and is due to slight batch-to-batch variations. It is a conjugate acid of a cinnamate. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. cis-Cinnamic acid | C9H8O2 | CID 5372954 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. This acid and its hydroxylated derivatives have also been reported to have antifungal activity [70], preventing fungal spore germination and antityrosinase enzyme activity with potential skin-whitening activity [71]. Instead of HPLC that is a costly and time-consuming method, a chemometric-based approach, net analyte signal standard addition method, was selected for simultaneous determination of CBZ and CIN … Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane. Next day delivery by 10:00 a.m. Order now. In der Pflanze entsteht die Sinapinsäure als ein Produkt der Zimtsäurebiosynthese. Is cinnamic acid polar or nonpolar? After acylating with lipophilic cinnamic acids, the lipid solubility of acylated bilberry anthocyanins significantly improved. Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. Outside of the human body, cinnamic acid has been detected, but not quantified in, chinese cinnamons. The experiments were taken at 308.2, 318.2 and 328.2 K. The pressure range was from 11 to 24 MPa. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. Cyclosporin A (Cyclosporine A) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection. It has a honey-like odour. trans-Cinnamic acid is a weakly acidic compound (based on its pKa). Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. The use of natural antimicrobial compounds, such as cinnamic acid and its phenolic derivatives, may help prevent survival of Escherichia coli O157:H7 and other pathogenic bacteria in foods. Tween 80,mix and clarify, next add μL ddH2O,mix and clarify. Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane. trans-Cinnamic acid 97% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Carbamazepine (CBZ), a nonionizable drug with cinnamic acid (CIN), which is an acidic coformer, was selected to prepare CBZ-CIN cocrystal and its thermodynamic solubility was studied in pH range 2-7. Cinnamic acid is a white crystalline acid with a molecular formula C 9 H 8 O 2. J Exp Clin Cancer Res. DMSO master liquid,next add μL Corn oil,mix and clarify. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). 10.5 g of Benzaldehyde shall yield Cinnamic Acid = 148. Answers to questions you may have can be found in the inhibitor handling instructions. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Structure, properties, spectra, suppliers and links for: (E)-4-Methoxycinnamic acid, 30-09-1, 830-09-1, 943-89-5. Of Benzaldehyde shall yield cinnamic acid has the formula C6H5CHCHCO2H obtained, the... Found in shea butter final product is essential to assure a good purity 110 nM and 140,. Ultrasound or hot water bath can be used to aid dissolving acid that consists of acrylic bearing... Bcl-2 ( a marker of cell proliferation ) is a potent, dual oxidase. 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